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Are There Differences Between Proton Pump Inhibitors?

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Updated June 27, 2011

Question: Are There Differences Between Proton Pump Inhibitors?
Answer: Proton Pump Inhibitors (PPIs) are similar in how they work, and there is no evidence that one is more effective than another. They differ, however, in how they are broken down by the liver and how they interact with other medications. Also, the effects of some PPIs may last longer than others and be taken less frequently.

PPIs include:

For more information on these medications, and others, go to Drugs A to Z.

Related Resources:

Sources:

Kenneth R. DeVault M.D., F.A.C.G., and Donald O. Castell M.D., M.A.C.G., "Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease." doi: 10.1111/j.1572-0241.2005.41217.x. American College of Gastroenterology. 6 Jun 2008

Nicholas J. Talley, M.D., Ph.D., F.A.C.G.,1 Nimish Vakil, M.D., F.A.C.G., "Guidelines for the Management of Dyspepsia." doi: 10.1111/j.1572-0241.2005.00225.x. American College of Gastroenterology. 6 Jun 2008

"Understanding Some of the Medications Often Prescribed for GERD & Ulcers." Common GI Problems: Volume 1. American College of Gastroenterology. 6 Jun 2008

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