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Prescription Remedies for Heartburn

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Type of Remedy Examples How They Work How Long They Last Why They Are Used
Proton Pump Inhibitors

(PPIs)

 • Aciphex
 • Nexium
 • Prevacid
 • Prilosec
 • Protonix
Deactivates acid pumps in the cells of the stomach, where stomach acid is produced. This thus inhibits the acid production. Up to 24 hours Short-term treatment of heartburn caused by gastroesophageal reflux disease (GERD).
H2 Blockers

(Histamine Receptor Antagonists)

 • Axid
 • Pepcid
 • Tagament
 • Zantac
Inhibits the action of histamine, which stimulates the secretion of stomach acid. This partially blocks the production of stomach acid 6 to 10 hours Short-term treatment of heartburn caused by gastroesophageal reflux disease (GERD). Longer treatment and higher doses are used for short-term treatment of erosive esophagitis.
Promotility Agents  • Reglan Causes the muscles in the stomach to contract, aiding in a faster emptying of the stomach. It also helps to strengthen the lower esophagus splinter (LES), which is the valve that blocks stomach contents from entering the esophagus. Up to 6 hours Heartburn and GERD


Chart of over-the-counter remedies


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