March 24, 2004Heartburn Blog Archives |
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Mechanisms of Acid RefluxThere are three disturbances in the normal gastrointestinal (GI) function that can lead to GERD.Poor Lower Esophageal Sphincter (LES) Tone When the LES is weak, it lacks the strength needed to hold back stomach contents. These erosive contents are allowed to back up (reflux) into the esophagus. Poor Esophageal Clearance In a normally-functioning esophagus, when reflux occurs, the esophagus has mechanisms that will push the refluxed materials back into the stomach. If these mechanisms do not work, or work properly, the erosive stomach contents may remain in the esophagus for a prolonged period of time. This can result in irritation, and sometimes damage, to the esophageal lining. Delayed Gastric Emptying When the food is not emptied from the stomach quickly enough, pressure builds in the stomach. This, then, puts increased pressure on the lower esophageal sphincter. When this happens, the LES may be forced to open inappropriately. Erosive stomach contents are then allowed to back up into the esophagus. 12:55 AM # |
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